| A study, "Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration," published in the most recent issue of the "PLoS Medicine" journal, http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050045 concluded that "... compared with placebo, the new-generation antidepressants do not produce clinically significant improvements in depression in patients who initially have moderate or even very severe depression, but show significant effects only in the most severely depressed patients." Based on your experience with your patients who are on SSRI drugs, do you agree or disgaree with this article's conclusion? | ||
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| # | Response Date | Other (please specify) |
| 1. | 3/3/2008 4:34:00 PM | Relative absence of side effects still make the SSRI's desirable to patients. |
| 2. | 3/5/2008 4:49:00 AM | I work in a large psychiatric hospital in India (NIMHANS). We see a range of patients. While everyone knows, antidepressants don't work well in all, it is too simplistic to assume that they don't work at all. Real life patients do benefit from SSRIs. SSRIs have been around for a very long time and we cannot base our conclusion only on pateints recruited for RCTs. |
| 3. | 3/5/2008 5:26:00 PM | Patients with a "mild" depression diagnosis are usually misdiagnosed. They are borderline personalities or tense-anxious personalities. |